Permeability / Solubility / Stability
Permeability methods offered are log P, log D, PAMPA Double-Sink ™ and caco-2 cell assays to mimic the GIT and BBB membranes. Solubility measurements using patented miniaturized shake flask, kinetic or thermodynamic solubility using buffers, FeSSif, FaSSIF, excipient or other media or user defined conditions are available.
API Sparing Dissolution
Small volume dissolution to detect differences amongst polymorphic compounds. Intrinsic dissolution rate using as low as 5 mg tablets available. Time versus concentration profiles for studying transient effects, super saturation and solubility rates available.
in vitro PK™ (Pharmaco-Kinetic) Profiles
Patented method that incorporates permeability, solubility and dissolution in one in vitro assay to rank compounds for correlation to in-vivo studies.
Biopharmaceutics Classification System (BCS) Profiles
Our expertise in measuring drug permeability, solubility and dissolution helps companies conform to FDA guidelines for BCS classification. The BCS bundled service is a cost effective way to screen either one or hundreds of compounds for physical property characterization.
Ionization
Expertise to measure pKa of compounds with low solubility, high MW, and multiple, overlapping ionization constants.
